2019 David Cushing Prize

Op-brai150131 2005..2019

Endophilin-B1, also known as Bax-interacting factor 1 (Bif-1, and encoded by SH3GLB1), is a multifunctional protein involved in apoptosis, autophagy and mitochondrial function. We recently described a unique neuroprotective role for neuron-specific alternatively spliced isoforms of endophilin-B1. To examine whether endophilin-B1-mediated neuroprotection could be a novel therapeutic target for A...

Harvey Cushing

NAPNAP research agenda: 2014-2019.

Regena Spratling, PhD, RN, CPNP, Rita H. Pickler, PhD, RN, PNP-BC, FAAN, Christina Calamaro, PhD, CRNP, Juanita Conkin Dale, PhD, RN, CPNP-PC, Sharron Docherty, PhD, RN, PNP-BC, FAAN, Catherine J. Goodhue, MN, CPNP, Jill Kilanowski, PhD, RN, APRN, CPNP, FAAN, Ann Marie McCarthy, PhD, RN, FAAN, Mary C. O’Laughlen, PhD, RN, FNP-BC, FAAAAI, Lois S. Sadler, PhD, RN, PNP-BC, FAAN, Leigh Small, PhD, ...

Preventing Cushing: Iatrogenic Cushing Syndrome due to Ritonavir-Fluticasone Interaction

Ritonavir is commonly used in low doses to boost plasma levels of protease inhibitors in patients with human immunodeficiency virus (HIV) infections. It is also a potent inhibitor of cytochrome P450. We present a 50-year-old African American male with past medical history of HIV on highly active antiretroviral therapy (HAART), which also included ritonavir and long standing asthma that has been...

Cushing ' S Syndrome

In 1932 Harvey Cushing described a number of patients presenting a similar clinical picture which he had collected from the literature, and he added two more from his own records. The presence of minute adenomata of basophil cells in the anterior lobe of the pituitary gland was demonstrated at autopsy on some of them and Cushing regarded these as the causative lesions and called the syndrome 'p...